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Jake Gyllenhaal Love and Other Drugs Premiere Red Carpet Interview

Jake Gyllenhaal speaks from the red carpet at the "Love and Other Drugs" movie premiere during AFI FEST 2010 at Grauman's Chinese Theatre on Nov. 4, 2010 in Hollywood, California.

Maggie is an alluring free spirit who won't let anything, including a formidable personal challenge, tie her down. But she meets her match in Jamie Randall, whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.

"Love and Other Drugs" opens in theaters nationwide on November 24.